Leucoselect® overview

Leucoselect® Phytosome®

Bioavailable standardized Grape seed procyanidins for the cardiovascular system

Antioxidant compounds such as polyphenols have been recognized to prevent degenerative processes related to chronic diseases. Polyphenols, commonly found in fruits and vegetables, are a key element of the Mediterranean diet, and have long been known for their capillary protective effects. Their beneficial effect for cardiovascular health has been demonstrated by scientific studies and clinical trials(1).

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    12. Natella, F., et al., Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. J Agric Food Chem, 2002. 50(26): p. 7720-5.
    13. Vigna G.B., Costantini F., Aldini G., Carini M., Catapano A., Schena F., Tangerini A., Zanca R., Bombardelli E., Morazzoni P., Mezzetti A., Fellin R., Maffei Facini R., Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers, Metabolism 52, 1250 (2003).
    14. Indena S.p.A., data on file.
    15. Maffei Facino R., Carini M., Aldini G., Bombardelli E., Morazzoni P., Morelli R., Free radicals scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera. A mechanism for their capillary protective action, Arzneim.-Forsch./Drug Res. 44, 592 (1994).
    16. Maffei Facino R., Carini M., Aldini G., Berti F., Rossoni G., Bombardelli E., Morazzoni P., Procyanidines from Vitis vinifera seeds protect rabbit heart from ischemia/reperfusion injury: antioxidant intervention and/or iron and copper sequestering ability, Planta Medica 62, 495 (1996).
    17. Maffei Facino R., Carini M., Aldini G., Calloni M.T., Bombardelli E., Morazzoni P., Sparing effect of procyanidins from Vitis vinifera on vitamin E: in vitro studies., Planta Medica 64, 343 (1998).
    18. Carini M., Stefani R., Aldini G., Ozioli M., Maffei Facino R., Procyanidins from Vitis vinifera seeds inhibit the respiratory burst of activated human neutrophils and lysosomal enzyme release, Planta Med. 2001 Nov;67(8):714-7.
    19. Aldini G., Carini M., Bombardelli E., Maffei Facino R., Polyphenols Communications 2002, XXI International Conference on Polyphenols,
    Marrakech, Morocco, September 9-12, 2002.
    20. Berti F., Manfredi B., Mantegazza P., Rossoni G., , Procyanidins from Vitis vinifera seeds display cardioprotection in an experimental model of ischemia-reperfusion damage, Drugs Exp Clin Res. 2003;29(5-6):207-16.
    21. Aldini G., Carini M., Piccoli A., Rossoni G., Maffei Facino R., Procyanidins from grape seeds protect endothelial cells from peroxynitrite damage and enhance endothelium-dependent relaxation in human artery: new evidences for cardio-protection., Life Sciences 73, 2883 (2003).
    22. Facino RM, Carini M, Aldini G, Berti F, Rossoni G, Bombardelli E, Morazzoni P., Diet enriched with procyanidins enhances antioxidant activity and reduces myocardial post-ischaemic damage in rats, Life Sci. 1999;64(8):627-42.
    23. Ursini F, Tubaro F, Rong J, Sevanian A., Optimization of nutrition: polyphenols and vascular protection, Nutr Rev. 1999 Aug;57(8):241-9.
    24. Study performed at the University of Milan, Institute of Pharmacological Sciences, School of Pharmacy, Prof. C. Galli. (Indena S.p.A., data on file).